Sivak, A.

No cancer risk from coffee Report - París (Francia) 1988 - p. 108-114

++ 6 tab. 27 ref. Sum. (En, Fr) p. 20-21

The consumption of coffee by large segments of the population has prompted the investigation of coffee as a risk factor in human cancer. The organ sites for cancer occurrence that have received the most attention are bladder, breast, colon and pancreas. Although positive weerk associations have been reported occasionally for each of these organ sites, the preponderance of the available information supports the view that coffee consumption is not a significant risk factor in cancer of the bladder, breast, colon and pancreas. The positive associations found may well be the consequence of other behavior and dietary patterns correlated with coffee consumption. A number of experimental studies have been carried out in mice and rats administering coffee for intervals as long as two years at levels up to the equivalent of 40-60 cups of coffee per day in humans. Uniformly in all of the reported studies, no increases in cancer at any site were noted. Similarly in long term studies with caffeine in experimental animals, no evidence was found relating caffeine to the induction of cancer. A few studies have shown that coffee consumption can modify in both a positive and negative manner the cancer inducing effects of strong carcinogens in the breast and pancreas of rats. The relevance of these findings to humans is unclear and questionable given the nature of the cancer inducing stimuli. The weight of evidence from all studies supports the view that usual dietary use of coffee does not pose a cancer risk


633.73063 / C714 1987